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Review Article
- Hypothalamus and Pituitary gland
- Precision Therapy in Acromegaly Caused by Pituitary Tumors: How Close Is It to Reality?
- Cheol Ryong Ku, Vladimir Melnikov, Zhaoyun Zhang, Eun Jig Lee
- Endocrinol Metab. 2020;35(2):206-216. Published online June 24, 2020
- DOI: https://doi.org/10.3803/EnM.2020.35.2.206
- 6,771 View
- 252 Download
- 8 Web of Science
- 8 Crossref
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Abstract
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ePub - Acromegaly presents with an enigmatic range of symptoms and comorbidities caused by chronic and progressive growth hormone elevations, commonly due to endocrinologic hypersecretion from a pituitary gland tumor. Comprehensive national acromegaly databases have been appearing over the years, allowing for international comparisons of data, although still presenting varying prevalence and incidence rates. Lack of large-scale analysis in geographical and ethnic differences in clinical presentation and management requires further research. Assessment of current and novel predictors of responsiveness to distinct therapy can lead to multilevel categorization of patients, allowing integration into new clinical guidelines and reduction of increased morbidity and mortality associated with acromegaly. This review compares current data from epidemiological studies and assesses the present-day application of prognostic factors in medical practice, the reality of precision therapy, as well as its future prospects in acromegaly, with a special focus on its relevance to the South Korean population.
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Citations
Citations to this article as recorded by
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Kyungwon Kim, Cheol Ryong Ku, Eun Jig Lee
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European Journal of Endocrinology.2023; 189(3): 363. CrossRef - The Future of Somatostatin Receptor Ligands in Acromegaly
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The Journal of Clinical Endocrinology & Metabolism.2022; 107(2): 297. CrossRef - Innovative therapeutics in acromegaly
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Best Practice & Research Clinical Endocrinology & Metabolism.2022; 36(6): 101679. CrossRef - Risk of Neurodegenerative Diseases in Patients With Acromegaly
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Neurology.2022;[Epub] CrossRef - Machine Learning-based Prediction Model for Treatment of Acromegaly With First-generation Somatostatin Receptor Ligands
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The Journal of Clinical Endocrinology & Metabolism.2021; 106(7): 2047. CrossRef - Skin anomalies in acromegalic patients (Review of the practical aspects)
Florica Sandru, Adelina Popa, Dan Paduraru, Alexandru Filipescu, Mara Carsote, Adina Ghemigian
Experimental and Therapeutic Medicine.2021;[Epub] CrossRef
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